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acadbd780c
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v1.0.0: VGAE applied to GM12878 vs IMR90 chr21 Hi-C at 25kb
Full reproducible pipeline: .mcool + ChIP-seq bigwigs → latent
embeddings → A/B compartment calls → cross-cell comparison.
Key results (chr21, 25 kb, latent dim=32):
- Test AUC=0.777, AP=0.759 (converged epoch 31/300)
- GM12878 A/B silhouette (cosine) = 0.775
- IMR90 zero-shot silhouette = 0.443
- A-compartment bins stable across cell types (mean cosine Δ=0.042)
- B-compartment bins shift substantially (mean cosine Δ=0.451)
- 101 B→A and 70 A→B compartment switches GM12878→IMR90
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2026-05-15 01:53:04 +02:00 |
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