aman
acadbd780c
Full reproducible pipeline: .mcool + ChIP-seq bigwigs → latent embeddings → A/B compartment calls → cross-cell comparison. Key results (chr21, 25 kb, latent dim=32): - Test AUC=0.777, AP=0.759 (converged epoch 31/300) - GM12878 A/B silhouette (cosine) = 0.775 - IMR90 zero-shot silhouette = 0.443 - A-compartment bins stable across cell types (mean cosine Δ=0.042) - B-compartment bins shift substantially (mean cosine Δ=0.451) - 101 B→A and 70 A→B compartment switches GM12878→IMR90
13 lines
239 B
JSON
13 lines
239 B
JSON
{
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"val_auc": 0.774052272942853,
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"test_auc": 0.7767560244060842,
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"test_ap": 0.7585872967832136,
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"epochs_ran": 31,
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"epochs_max": 300,
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"patience": 20,
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"hidden": 64,
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"latent": 32,
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"dropout": 0.2,
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"lr": 0.001,
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"seed": 42
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} |