aman
acadbd780c
Full reproducible pipeline: .mcool + ChIP-seq bigwigs → latent embeddings → A/B compartment calls → cross-cell comparison. Key results (chr21, 25 kb, latent dim=32): - Test AUC=0.777, AP=0.759 (converged epoch 31/300) - GM12878 A/B silhouette (cosine) = 0.775 - IMR90 zero-shot silhouette = 0.443 - A-compartment bins stable across cell types (mean cosine Δ=0.042) - B-compartment bins shift substantially (mean cosine Δ=0.451) - 101 B→A and 70 A→B compartment switches GM12878→IMR90
231 B
231 B
| 1 | label | n_bins | latent_dim | mean_embedding_norm | std_embedding_values | silhouette_AB_cosine |
|---|---|---|---|---|---|---|
| 2 | GM12878 | 1869 | 32 | 0.6679670810699463 | 0.1371903121471405 | 0.7748898267745972 |
| 3 | IMR90 | 1869 | 32 | 0.7111130356788635 | 0.14772675931453705 | 0.4431541860103607 |