v1.0.0: VGAE applied to GM12878 vs IMR90 chr21 Hi-C at 25kb
Full reproducible pipeline: .mcool + ChIP-seq bigwigs → latent embeddings → A/B compartment calls → cross-cell comparison. Key results (chr21, 25 kb, latent dim=32): - Test AUC=0.777, AP=0.759 (converged epoch 31/300) - GM12878 A/B silhouette (cosine) = 0.775 - IMR90 zero-shot silhouette = 0.443 - A-compartment bins stable across cell types (mean cosine Δ=0.042) - B-compartment bins shift substantially (mean cosine Δ=0.451) - 101 B→A and 70 A→B compartment switches GM12878→IMR90
This commit is contained in:
1870
results/figures/chr21_delta.csv
Normal file
1870
results/figures/chr21_delta.csv
Normal file
File diff suppressed because it is too large
Load Diff
BIN
results/figures/chr21_delta.png
Normal file
BIN
results/figures/chr21_delta.png
Normal file
Binary file not shown.
|
After Width: | Height: | Size: 219 KiB |
BIN
results/figures/umap_GM12878_compartment.png
Normal file
BIN
results/figures/umap_GM12878_compartment.png
Normal file
Binary file not shown.
|
After Width: | Height: | Size: 189 KiB |
BIN
results/figures/umap_GM12878_position.png
Normal file
BIN
results/figures/umap_GM12878_position.png
Normal file
Binary file not shown.
|
After Width: | Height: | Size: 238 KiB |
BIN
results/figures/umap_IMR90_compartment.png
Normal file
BIN
results/figures/umap_IMR90_compartment.png
Normal file
Binary file not shown.
|
After Width: | Height: | Size: 204 KiB |
BIN
results/figures/umap_IMR90_position.png
Normal file
BIN
results/figures/umap_IMR90_position.png
Normal file
Binary file not shown.
|
After Width: | Height: | Size: 267 KiB |
BIN
results/figures/umap_joint.png
Normal file
BIN
results/figures/umap_joint.png
Normal file
Binary file not shown.
|
After Width: | Height: | Size: 304 KiB |
3
results/figures/umap_stats.csv
Normal file
3
results/figures/umap_stats.csv
Normal file
@@ -0,0 +1,3 @@
|
||||
label,n_bins,latent_dim,mean_embedding_norm,std_embedding_values,silhouette_AB_cosine
|
||||
GM12878,1869,32,0.6679670810699463,0.1371903121471405,0.7748898267745972
|
||||
IMR90,1869,32,0.7111130356788635,0.14772675931453705,0.4431541860103607
|
||||
|
Reference in New Issue
Block a user