aman
acadbd780c
Full reproducible pipeline: .mcool + ChIP-seq bigwigs → latent embeddings → A/B compartment calls → cross-cell comparison. Key results (chr21, 25 kb, latent dim=32): - Test AUC=0.777, AP=0.759 (converged epoch 31/300) - GM12878 A/B silhouette (cosine) = 0.775 - IMR90 zero-shot silhouette = 0.443 - A-compartment bins stable across cell types (mean cosine Δ=0.042) - B-compartment bins shift substantially (mean cosine Δ=0.451) - 101 B→A and 70 A→B compartment switches GM12878→IMR90
4 lines
231 B
CSV
4 lines
231 B
CSV
label,n_bins,latent_dim,mean_embedding_norm,std_embedding_values,silhouette_AB_cosine
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GM12878,1869,32,0.6679670810699463,0.1371903121471405,0.7748898267745972
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IMR90,1869,32,0.7111130356788635,0.14772675931453705,0.4431541860103607
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